Moderna's cancer vaccine clinical data was released at 00:30. On Hyperliquid, 362,000 mRNA contracts were traded in three hours, with a peak 24-hour trading volume of $104 million. The notional open interest of mRNA contracts surged from $6.84 million to $20.31 million, and open interest increased from 30,500 contracts to 108,800 contracts, before subsequently falling back to $6.27 million and 30,900 contracts. One account established a short position of 6,310.91 mRNA contracts, worth approximately $1.283 million, with an average entry price of $188.304, and is currently experiencing a floating loss of approximately $95,000.

On October 23, London spot gold fell more than 2.80%, hitting a low of $4,020. The COMEX New York gold December contract closed down 2.16%, and the SHFE Shanghai gold futures contract closed down 1.88% in the night session. A sell-off in US AI stocks triggered liquidity demand, leading to a single-day reduction of 11.97 tons in holdings by the world's largest gold ETF, SPDR, to 1,045.64 tons. US initial jobless claims fell to 194,000 last week, and pending home sales contracts in September decreased by 7.3% month-over-month. The US and Israeli militaries are developing a military strike plan targeting Iranian energy and nuclear facilities, increasing uncertainty in the Middle East and raising market expectations for interest rate hikes. (Source: Everbright Futures) AI Interpretation: The number of initial jobless claims fell to a historic low this week, directly demonstrating the strong resilience of the US labor market during this tightening cycle. This robust data weakened market concerns about an economic recession and provided solid macroeconomic support for the Federal Reserve to maintain its high-interest-rate policy. The continued strength of the job market has forced investors to reassess their interest rate cut path, thereby suppressing demand for safe-haven assets. This data clearly points to a continued tightening monetary policy, putting direct downward pressure on precious metal prices.

Global credit spreads rise to 17 month high, AI investment sparks divergence Affected by the sell-off of artificial intelligence stocks and geopolitical factors, the global corporate bond yield premium has risen to 129 basis points, marking the largest spread since May 2025. Investors worried about AI spending speed and short-term profits. Griffin, CEO of Citadel Securities, warned that there was a foam, while Jon Gray, President of Blackstone Group, believed that market demand grew strongly. (Source: Jin Shi)

An Ethereum OG who bought 3,000 ETH at an average price of $18.83 nine years ago sold them today, making a 128-fold profit. The ETH is now worth $7.23 million.

The Coinbase Pro IRYS/USD price hit a nearly 3-month high, currently trading at $0.02793, up 27.87% in the last 24 hours, with a trading volume of $3.27 million. After reaching a new high, a price correction is highly likely. (AiCoin Research Institute)