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**[OpenAI's Second-in-Command Fidji Simo Steps Down Due to Illness, Less Than a Year in Role]** According to monitoring by Beating, Fidji Simo, the AGI Deployment CEO at OpenAI, has announced her departure from her full-time position to transition into a part-time advisory role. Three months ago, she began a leave of absence due to the worsening of a chronic illness, and it has now been confirmed that her recovery process is taking longer than expected, requiring her to focus on treatment. Simo is a key executive at OpenAI, second only to Sam Altman. She previously served as the CEO of the U.S. fresh grocery delivery platform Instacart and was also responsible for the Facebook App. After joining OpenAI in 2025, she oversaw the product and commercial teams, covering businesses such as ChatGPT and Codex, before later transitioning to the role of AGI Deployment CEO. In April of this year, Simo took a leave of absence due to a neuroimmune disease, initially planning to be away for only a few weeks. Since then, OpenAI President Greg Brockman has taken over product-related responsibilities. Her former product and commercial duties are expected to be shared among Brockman, CFO Sarah Friar, and Chief Strategy Officer Jason Kwon. Simo stated that she has been living with the chronic illness for seven years, and there is currently no cure. In the future, in addition to continuing her advisory role at OpenAI, she plans to participate in AI biomedical projects Chronicle BioAI and CODA Research. [Original Link]